长期使用抗抑郁药在澳大利亚的患病率增加:一项回顾性观察性研究
R A D L M K Ranwala1, Elizabeth E Roughead1, Jean-Pierre Calabretto2
1Quality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Pharmacoepidemiology and drug safety
|November 15, 2025
概括
长期使用抗抑郁药正在增加,特别是在10-24岁的年轻人中. 延长治疗持续时间和最小的剂量减少表明潜在的过度处方和需要更好的降低处方策略.
科学领域:
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 长期使用抗抑郁药可能会因为戒断症状和副作用而对风险效益平衡产生负面影响.
- 长期使用抗抑郁药物被定义为持续使用至少365天,可允许的分发间隔长达60天.
- 从2014年到2023年,调查澳大利亚社区长期使用抗抑郁药的历史趋势.
研究的目的:
- 分析澳大利亚长期使用抗抑郁药的流行病学趋势.
- 检查长期使用抗抑郁药物的特定年龄模式.
- 评估随着时间的推移,治疗持续时间和剂量减少策略的变化.
主要方法:
- 对10%的澳大利亚制药福利计划 (PBS) 数据样本进行了回顾性分析.
- 包括在2014年1月至2023年12月期间分发PBS列出的抗抑郁药的10岁以上的患者.
- 检查患病率,年龄分层的趋势,治疗持续时间和明显的剂量减少.
主要成果:
- 长期使用抗抑郁药的患病率从每千人中66.1上升到每千人中84.6 (2014-2023年).
- 10-24岁的年龄组长期使用者流行率 (110%) 和比例 (35%) 的相对增加最高.
- 平均治疗持续时间总体增加了25%,在10-24岁组增加了56%,明显的剂量减少仍然很小.
结论:
- 在所有年龄组,特别是青少年和年轻成年人中,长期使用抗抑郁药物的显着增加.
- 延长治疗持续时间和有限的剂量减少表明潜在的过度处方和使用不足的抑郁症.
- 需要综合心理健康方法,包括有效的抑郁症和技术干预措施.
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