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[¹⁸F]FDG PET/CT揭示了肺癌中的HPA轴过活:预后价值和治疗潜力

Meng Liang^1,2,3, Caozhe Cui^1,2,3, Xiaomeng Li^1,2,3

¹Department of Nuclear Medicine, First Hospital of Shanxi Medical University, No. 85 South Jiefang Road Taiyuan, 030001, Shanxi, People's Republic of China.

European journal of nuclear medicine and molecular imaging

|November 15, 2025

概括

肺癌患者显示下丘脑-垂体-上腺 (HPA) 轴活动增加,特别是在上腺,影响预后. 与化疗和HPA轴抑制剂的联合治疗在临床前模型中改善了生存率.

科学领域:

核医学成像技术核医学成像技术
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

下垂体-垂体-上腺 (HPA) 轴在应激反应和代谢调节中起着至关重要的作用.
改变HPA轴活性与包括癌症在内的各种疾病有关.

研究的目的:

为了评估肺癌患者的HPA轴活性,使用18F-FDG PET/CT.
探索HPA轴活性在肺癌中的预后意义.
在临床前肺癌模型中调查针对HPA轴的治疗潜力.

主要方法:

对151名肺癌患者和94名对照患者的18F-FDG PET/CT图像进行了回顾性分析.
两组之间对HPA相关器官的代谢活性进行比较.
生存分析 (卡普兰-梅尔,考克斯回归) 来评估预后影响.
在肺癌小鼠模型中评估组合疗法 (化疗+普拉诺洛尔).

主要成果:

与对照组相比,肺癌患者在上腺,肌肉,脂肪,生殖腺和垂体中表现出较高的代谢活性.
特定的大脑区域显示了新陈代谢的改变.
右上腺SUVmean,脂肪SUVmax和总损伤糖解是独立的预后因素.
组合疗法在小鼠中改善了体重,运动功能,并减少了瘤葡萄糖代谢.

结论:

18F-FDG PET/CT揭示了肺癌中HPA轴器官活性增加,上腺过度代谢可能会使预后恶化.
在临床前模型中,将β-阻断剂与化疗结合针对HPA轴显示出显著的生存益处.

关键词:

德国联邦航空公司 (FDG)在HPA轴上.肺癌是一种肺癌.肌肉肌肉肌肉肌肉聚乙烯/聚乙烯/聚乙烯预测预后预测预测

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