在泌尿癌中治疗术后便秘的预防性松剂使用:现实世界的队列研究
Wasilijiang Wahafu1,2, Feiya Yang1, Tiejun Yang3
1Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
World journal of urology
|November 15, 2025
概括
预防性松剂的使用显著减少了泌尿癌患者的术后便秘. 与基于症状的治疗相比,这种方法改善了肠道排便频率和生活质量.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 手术后便秘是接受泌尿癌手术的患者常见的并发症.
- 需要有效的预防策略来改善患者的治疗结果和生活质量.
研究的目的:
- 为了比较预防性松剂使用与基于症状的治疗在接受尿道癌症手术的患者中预防便秘的有效性.
主要方法:
- 一项非随机研究涉及1,724名接受泌尿癌手术的患者.
- 患者被分配到预防性药组 (n=965) 或基于症状的治疗组 (n=748).
- 倾向性得分匹配用于控制基线差异;主要结果是手术后7天内便秘的发生率.
主要成果:
- 术后便秘的发生率在预防性松剂组 (12.3%) 与基于症状的组 (42.7%) 相比显著较低.
- 接受预防性药的患者有更高的完全自发性肠道排便 (CSBM) 率,并改善了患者对便秘生活质量 (PAC-QOL) 和症状 (PAC-SYM) 评价的得分.
- 术后便秘的独立风险因素包括年龄,便秘诊断,预防性药使用和基线CSBM.
结论:
- 预防性松剂的使用是有效的减少患有泌尿器官瘤的患者的术后便秘的发生率.
- 这些发现提供了初步证据,以指导临床医生识别和管理患有术后便秘风险的患者.
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