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综合和定量性尿道代谢学概况,以更好地表征糖尿病病

Yamilé López-Hernández^1,2, Juan José Oropeza-Valdez³, Valeria Maeda-Gutiérrez⁴

¹SECIHTI-Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico.

Metabolomics : Official journal of the Metabolomic Society

|November 15, 2025

概括

糖尿病病 (DN) 显示出明显的尿路代谢变化,包括氧化应激和炎症标志物. 一组代谢物,包括β-alanine和kynurenine,显示了早期,非侵入性DN诊断的希望.

科学领域:

生物化学生物化学
代谢学代谢学代谢学
腎臟病學 (nephrology) 是一種醫學.

背景情况:

糖尿病病 (DN) 是慢性病和末期功能衰竭的主要原因.
目前的诊断标志物,如白蛋白尿,缺乏特异性,并且很晚发现损伤.
尿代谢分析为更早,更具体的检测提供了潜在的途径.

研究的目的:

在患有糖尿病病 (DN) 的患者中描述尿路代谢变化.
为了确定潜在的代谢物面板用于DN的非侵入性诊断.
探索代谢学在理解DN病理生理学的有用性.

主要方法:

使用TMIC尿液MEGA检测量268种代谢物的向性尿代谢分析.
分析了来自60名参与者的样本:20名对照组,20名2型糖尿病患者 (DM-2) 和20名DN患者.
统计分析包括部分最小平方区分分析 (PLS-DA) 和处罚回归 (LASSO,弹性网) 与后勤回归.

主要成果:

DN患者表现出与氧化应激,线粒体功能障碍和炎症相关的代谢物的显著变化.
一个由四种代谢物 (β-alanine, kynurenine,葡萄糖,阿尔基尼酸) 组成的小组区分了DN患者,其AUC为0.905.5.
包括估计的淋巴膜过率 (GFR) 和额外的代谢物,改善了诊断性能 (AUC=0.96).

结论:

定量性泌尿代谢学揭示了DNA中的关键代谢干扰.
候选代谢物板显示了非侵入性DN表征和诊断的潜力.
需要在更大的队列中进一步验证,以将代谢学纳入糖尿病病的精确诊断.

关键词:

生物标志物生物标志物糖尿病糖尿病糖尿病糖尿病脏病糖尿病脏病代谢产物的代谢物有针对性的代谢组学.尿液尿液尿液

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