通过综合转录组分析,识别与糖尿病后代的sevoflurane诱导的突触损失相关的枢纽基因和途径

Xiaoru Sun1, Xinke Guo1, Tingmei Wu1

  • 1Department of Anesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.

Metabolic brain disease
|November 15, 2025
PubMed
概括

孕期糖尿病可以放大sevoflurane对年轻大脑的伤害. 这项研究揭示了主要微质细胞的关键基因,增加了糖尿病后代的神经毒性和突触损失,提供了潜在的治疗点.