在慢性鼻炎中,S100A4通过TLR4通路诱导通过鼻多的中性性炎症
Yanyi Tu1,2,3,4, Chunhao Li1,5, Tao Li1,2,3,4
1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Journal of clinical immunology
|November 15, 2025
概括
在患有鼻息肉 (CRSwNP) 的慢性鼻炎患者中,S100A4蛋白升高,特别是在患有中性友炎症的患者中. 它通过TLR4通路促进鼻上皮细胞的炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 在慢性鼻炎中用鼻息肉 (CRSwNP) 治疗中性友炎是具有挑战性的.
- 控制中性粒细胞透和激活是CRSwNP结果的关键.
- 一种结合的蛋白质S100A4会影响细胞迁移,化学反应和纤维化.
研究的目的:
- 研究S100A4在CRSwNP中中性友炎症中的作用.
- 探索S100A4参与托尔类受体4 (TLR4) 信号传输的可能性.
主要方法:
- 定量RT-PCR和免疫光分析了S100A4在鼻腔粘膜中的表达和分布.
- 原始人类鼻上皮细胞 (hNECs) 用S100A4进行治疗,以评估细胞因子/化学因子的产生.
- 使用TLR4抑制剂 (TAK-242) 来确定S100A4是否通过TLR4通路起作用.
主要成果:
- 在CRSwNP患者中,S100A4 mRNA和S100A4+细胞数量增加,与中性粒细胞有很强的相关性.
- 主要发现S100A4在自身层中的中性粒细胞中.
- 在hNEC中,S100A4治疗调高了中性粒细胞化学基因和IL-36γ,由TLR4.4介导.
结论:
- 在中性友好的CRSwNP中,S100A4的含量升高.
- S100A4促进了对鼻上皮细胞的促炎作用.
- S100A4通过TLR4信号级联发挥其作用.
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