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Updated: Jan 11, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
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结合体质突变和转录组分析,揭示了人类皮层中克隆结构的区域特异性差异.

Vinayak V Viswanadham1, Sonia N Kim2, Emre Caglayan3

  • 1Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, MA, USA.

Cell reports
|November 15, 2025
PubMed
概括

人类大脑发育揭示了独特的细胞谱系模式. 研究人员在超过72,000个细胞中绘制了体质单核酸变体 (sSNVs),发现了克隆分散和神经元类型晚 divergence 的区域差异.

关键词:
CP:基因组学 在CP:基因组学.在CP:神经科学.皮层发育 皮层发育谷氨酸作用的神经元内部神经元内部神经元谱系追踪 谱系追踪 谱系追踪单细胞转录组学 单细胞转录组学身体突变 - 身体突变空间基因组学的空间基因组学视觉皮层 视觉皮层 视觉皮层

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