相关实验视频
Updated: Jan 11, 2026

08:43
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
68.7K
凝血功能指标和肠功能障碍标志物的关联与肠道功能障碍的败血症患者的临床结果
Jing Ma1, Fan Yang2, Gaifeng Liu3
1Department of Critical Care Medicine, Guyuan People's Hospital, Guyuan 756000, Ningxia Hui Autonomous Region, China.
概括
凝血和肠道标志物,如D-二聚合物和d-乳酸盐,与患有胃肠道问题的败血症患者的结果有关. 这些指标可以帮助预测患者的生存率,并为治疗策略提供信息.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
背景情况:
- 败血症是一种危及生命的系统性炎症反应感染.
- 胃肠道功能障碍是败血症患者的常见并发症.
- 了解影响败血症结果的因素对于患者管理至关重要.
研究的目的:
- 调查凝血功能指标和肠功能障碍标志物与患有肠道功能障碍的败血症患者临床结果之间的关联.
- 确定该患者群体中死亡率的预测标志物.
主要方法:
- 研究了一组105名患有肠胃功能障碍的败血症患者.
- 凝血标志物 (血小板,纤维素,D-二次体) 和肠道标志物 (内毒素,d-乳酸盐) 在入院时被测量.
- 患者根据28天生存状态被分类.
主要成果:
- 亚帕希II评分,索法评分,D-二聚合物和d-乳酸盐显著影响了临床结果 (P<0.05).
- 综合标志物显示出高灵敏度 (77.74%) 和特异性 (83.87%) 预测死亡,AUC为0.868.8%.
- 像纤维素原,D-二聚体和内毒素这样的单个标记物也显示出预测价值.
结论:
- 凝血功能指标和肠功能障碍标志物与肠道功能障碍的败血症患者的临床结果有显著的相关性.
- 这些标记物作为预测预后和指导毒症管理临床决策的宝贵工具.
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
880
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
880
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
622
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
622
Serum Laboratory Studies, Stool Test, Breath Test
738
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
738
Inflammatory Bowel Disease II: Crohn's Disease
939
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
939
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
522
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
522

