相关实验视频

Updated: Jan 11, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

光触发的纳米酶系统放大了氧化应激,用于精确的癌症治疗

Yalong Wu¹, Xinquan Gu¹, Yang Li¹

¹Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

Colloids and surfaces. B, Biointerfaces

|November 15, 2025

概括

这项研究引入了一种新的Pd@CPT纳米酶系统,可以放大氧化应激,从而改善癌症治疗. 它利用光触发释放的坎普托 (CPT) 来提高过氧化 (H2O2) 水平,提高纳米酶的有效性和光热处理.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

具有过氧化酶类活性的纳米酶通过产生细胞毒性基来显示出对癌症治疗的希望.
在瘤中有限的过氧化 (H2O2) 限制了纳米酶的有效性.
坎普托西因 (CPT) 可以增加H2O2水平,可能增强基于纳米酶的疗法.

研究的目的:

开发一种光触发系统,将 (Pd) 纳米酶和CPT结合起来,以增强抗瘤活性.
为了克服瘤微环境中的H2O2缺乏.
研究光热疗法,纳米酶催化剂和化疗的协同效应.

主要方法:

在聚乙烯醇 (PVA) 矩阵 (Pd@CPT系统) 中,Pd纳米酶和CPT的联合封装.
近红外 (NIR) 光触发了Pd纳米酶和CPT的受控释放.
CPT激活NADPH氧化酶以增加瘤H2O2水平,增强Pd纳米酶的类似过氧化酶的活性.
评估协同作用的抗瘤效应,包括氧化应激放大和免疫细胞死亡.

主要成果:

在NIR照射下,Pd@CPT系统有效地提供Pd纳米酶和CPT.
CPT显著增加了内H2O2,提高了Pd纳米酶的催化效率.
联合光热和纳米酶疗法显示出协同作用的抗瘤效应和增强的免疫反应.
该系统显示了精确癌症治疗的潜力,降低了目标外毒性.

结论:

开发的光触发Pd@CPT系统成功地放大了氧化应激,以加强癌症治疗.
这种方法有效地解决了瘤中的H2O2限制,改善了纳米酶的性能.
疗法的协同作用组合为精确的癌症治疗提供了一个有前途的战略.

关键词:

膀癌是一种癌症.免疫治疗是一种免疫疗法.纳米酶纳米酶是一种纳米酶.光热疗法是一种光热疗法.有反应性氧物种的反应性氧物种.

更多相关视频

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Published on: February 3, 2017

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

相关概念视频

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...