在多发性硬化症的过程中,从适应到不适应的海马休息状态功能连接,以了解记忆障碍
Judit Salavedra-Pont1, Clàudia Coll-Martinez2, Ana Quiroga-Varela3
1Girona Neuroimmunology and Multiple Sclerosis Unit, Neurology Department, Dr. Josep Trueta University Hospital and Santa Caterina Hospital, Girona/Salt, Spain; Neurodegeneration and Neuroinflammation Research Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Salt, Spain; Department of Psychology, Universitat de Girona, Spain.
NeuroImage. Clinical
|November 15, 2025
概括
在多发性硬化症 (MS) 阶段,海马体的休息状态功能连接 (rsFC) 发生变化,最初补偿白质病变,但后来对记忆变得无益. 这些rsFC转移了MS的并行记忆衰退.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 多发性硬化症 (MS) 中白质病变对记忆的影响受到海马休息状态功能连接 (rsFC) 的影响,但这种关系尚未完全理解.
- 调查海马体的rsFC变化如何在不同的MS临床阶段影响记忆是至关重要的.
研究的目的:
- 确定每一个MS临床阶段的海马 rsFC变化是否以及如何调节WM病变对记忆表现的负面影响.
- 探索整个多发性硬化症进展过程中海马 rsFC 的动态变化及其与认知功能的关联.
主要方法:
- 一项涉及109名参与者的横截面研究:30名健康对照组,20名临床或放射学隔离综合征 (CIS/RIS),24名复发性复发性多发性硬化症 (RRMS) 和35名进展性多发性硬化症 (PMS).
- 用Rey的听觉语言学习测试来评估语言记忆.
- 磁共振成像用于量化WM病变和海马 rsFC,通过统计分析,包括线性回归,ANOVA和t测试.
主要成果:
- 记忆表现在CIS/RIS中得到保留,但在RRMS和PMS中逐渐受损.
- 海马的rsFC显示了依赖阶段的变化:CIS/RIS中增加的海马角的rsFC建议补偿.
- 在RRMS和PMS中,与前额和后额皮层相结合的改变的海马 rsFC与记忆保存无关,表明无益的重组.
结论:
- 海马 rsFC 经历了从涉及默认模式网络区域的补偿机制过渡到后期MS阶段的不适应性重组.
- 这些不断变化的rsFC模式与记忆障碍的进展相关,从MS阶段的功能保存到功能下降.
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