前环状皮质中的金字塔体大小在精神分裂症中很小,与幻觉得分相关
Ryuta Mizutani1, Rino Saiga2, Yoshiro Yamamoto3
1Department of Bioengineering, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan; RIKEN SPring-8 Center, Kouto, Sayo, Hyogo 679-5148, Japan.
精神分裂症患者在前带皮质中表现出显著较小的神经元细胞体. 这种soma缩小,加上神经元稀薄,可能解释了灰质减少和精神分裂症的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 精神病学是一个精神病学.
背景情况:
- 卷积灰质减少是精神分裂症的一个标志.
- 观察到宏观的前带带皮层 (ACC) 减少,但细胞机制尚不清楚.
研究的目的:
- 在精神分裂症中的ACC中调查神经元 soma结构的细胞水平变化.
- 为了将细胞形态与临床症状和先前观察到的神经元异常相关联.
主要方法:
- 同步辐射纳米计算机断层扫描 (纳米CT) 用于分析神经元的 soma 结构.
- 进行了对 soma 长度和神经元曲率标准偏差的定量分析.
- 8例精神分裂症病例与8例对照病例的比较.
主要成果:
- 精神分裂症患者的平均 soma 长度显著减少 (80%的对照组,p=0.00085).
- 索马长度和神经元曲率有效地区分了精神分裂症与对照组.
- 神经 soma 长度与幻觉严重程度负相关 (r=-0.52,p=0.037).
结论:
- 在ACC中神经 soma缩小,有助于在精神分裂症中灰质的缩小.
- 结合神经元稀薄, soma缩小可能是精神分裂症功能缺陷的基础.
- 这些细胞变化提供了宏观发现和精神分裂症的病理生理学之间的机械联系.
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