肠道微生物群衍生代谢物调节骨外细胞矩阵恒常:机制和治疗影响
Yuanliang Li1, Kai Liu1, Yugu Li1
1College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Cellular signalling
|November 15, 2025
概括
肠道微生物群代谢物通过影响骨细胞外基质 (ECM) 来调节骨健康. 准这些代谢物为治疗骨质疏松症和骨关节炎等骨疾病提供了一个有希望的策略.
科学领域:
- 微生物学和骨生物学
- 肠 - 骨轴研究研究
- 代谢学和骨质恒温学 骨质恒温学
背景情况:
- 骨细胞外矩阵 (ECM) 完整性对骨健康至关重要,其失调与骨质疏松症,骨质疏松症和骨关节炎有关.
- 肠道微生物群通过其多样化的代谢产物显著影响骨质稳定.
- 微生物的主要代谢物包括短链脂肪酸 (SCFA),醇代谢物,胆酸 (BA) 和细菌细胞外囊泡 (BEV).
研究的目的:
- 审查了解肠道微生物群代谢物如何调节骨 ECM 生物合成和重塑的最新进展.
- 突出针对骨疾病的微生物代谢物的治疗潜力.
- 强调阐明分子机制对于临床翻译的重要性.
主要方法:
- 对肠道微生物群代谢物和骨健康的临床前和临床研究的文献综述.
- 通过微生物代谢物调节骨 ECM 恒温的途径的分析.
- 对影响骨部件的代谢物与宿主相互作用的当前知识的综合.
主要成果:
- 微生物代谢物通过增强矿物质吸收和调节免疫和内分泌信号 (例如GH/IGF-1,AhR/PXR,FXR/TGR5) 来调节骨 ECM 稳态.
- 这些代谢物影响骨细胞分化和活性,影响原体矿化和非原蛋白表达.
- 临床前研究表明,在骨疾病中,微生物群衍生代谢物的治疗有前途.
结论:
- 准肠道微生物群代谢物是一种有前途的策略,通过协调ECM平衡来促进骨健康.
- 需要进一步的研究来充分阐明分子机制,并将发现转化为临床应用.
- 了解肠道微生物群-骨轴为创新的骨健康干预提供了新的见解.
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