双相情感障碍患者的结构功能合的变化,自杀念头与时间型相关
Yujue Wang1, Junchen Bao2, Junling Sheng2
1Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing 210093, China; Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Journal of affective disorders
|November 15, 2025
概括
双极性障碍患者具有自杀念头显示改变了大脑连接和显著的晚间时间型. 这些发现表明,在双相情感障碍中管理自杀行为有潜在的慢性治疗策略.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 时间生物学 时间生物学
背景情况:
- 双极性障碍 (BD) 与高自杀风险有关.
- 自杀念头 (SI) 在BD与晚间时刻型相关,但底层的神经成像机制尚不清楚.
- 单模MRI可能缺乏检测合结构功能异常的灵敏度.
研究的目的:
- 研究双相情绪障碍患者 (BD-SI) 与没有 (BD-nSI) 和健康对照者 (HC) 相比,改变结构连接功能连接 (SC-FC) 的合.
- 在BD-SI患者中探索SC-FC合,自杀念头和时间型之间的相关性.
主要方法:
- 招募了138名BD-SI,46名BD-nSI和280名HC参与者.
- 获得的静止状态功能性MRI (rs-fMRI) 和扩散张力成像 (DTI) 数据.
- 使用早晨-晚上问卷 (MEQ) 评估时间型,并比较跨组的SC-FC合.
主要成果:
- 确定了一种改变的功能连接网络,涉及尾状核,面,补充运动区域,后中心环,下环和状环.
- 与BD-nSI和HC患者相比,BD-SI患者表现出明显的晚间年代型变化和右下额头 (IFGtriang.R) 中的SC-FC合减少.
- 两组BD小组在右嗅皮层 (OLF.R) 与HC中的SC-FC合减少,BD-SI患者在右桃体 (AMYG.R) 与BD-nSI中的合增加.
结论:
- 双极性障碍患者的自杀念头显示出SC-FC合的显著变化和明显的晚间时间型.
- 在BD-SI中改变的大脑连接和时间型的融合需要进一步的研究.
- 这些发现表明,在治疗双相情绪障碍患者的自杀行为方面,有潜在的时间治疗干预措施.
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