二沃斯的神经血管毒性:内皮功能障碍和神经退行症之间的交叉声
Igbayilola Yusuff Dimeji1, Ngabea Murtala2, Adekola Saheed Ayodeji3
1Human Physiology Department, Baze University, College of Medicine and Health Sciences, Abuja, Nigeria.
Toxicology letters
|November 15, 2025
概括
酸有机农药二 (DDVP) 通过破坏血脑屏障和内皮细胞引起神经毒性,导致神经退行,超出其已知的急性作用.
科学领域:
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
- 环境健康 环境健康
背景情况:
- O,O-Dimethyl O-(2,2-dichlorovinyl) 酸盐 (DDVP),或二,是一种广泛使用的有机杀虫剂,特别是在低收入和中等收入国家.
- 虽然通过乙胆酶抑制已知其急性神经毒性,但新出现的证据表明它对神经血管系统的慢性影响.
- 内皮功能障碍和血脑屏障 (BBB) 的破坏被确定为早期事件,将DDVP诱导的血管损伤与神经退行联系起来.
研究的目的:
- 综合当前对DDVP诱导的神经血管毒性的机制性见解.
- 突出神经血管单元作为有机酸盐中毒的关键目标.
- 探索内皮功能障碍和神经元损伤之间的相互作用,以改善风险评估和治疗策略.
主要方法:
- 在包括PubMed,Scopus,Web of Science,ScienceDirect,EMBASE和Tox.Net在内的数据库中进行了全面的文献搜索.
- 搜索术语包括"二沃斯"",DDVP"",有机类农药"",神经毒性"",内皮功能障碍"",血脑屏障"",神经退行"",氧化应激"和"交叉".
- 纳入标准侧重于同行评审的英语研究 (2000-2025年),报告了关于DDVP诱导的神经血管毒性的体内和体外实验数据.
主要成果:
- DDVP通过破坏氧化应激,氧化和炎症信号的稳定性来损害内皮完整性.
- 这种内皮损伤损害了BBB的透性,允许神经毒素和细胞因子进入中枢神经系统.
- 其后果包括神经元亡,线粒体功能障碍和神经炎症,表明神经血管交叉声驱动的神经退行.
结论:
- 由DDVP诱导的神经毒性超越胆固醇机制,包括神经血管驱动的退化.
- 神经血管单元是DDVP中毒的关键目标.
- 了解内皮功能障碍与神经损伤的联系为管理与农药有关的神经退行性疾病提供了新的途径.
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