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Updated: Apr 11, 2026

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使用原子层沉积制备的无脂质,热稳定的mRNA疫苗

Holly J Coleman1, Amber Rauch2, Erika Langsfeld2

  • 1Department of Chemical and Biological Engineering, University of Colorado Boulder, CO 80303, USA.

Journal of pharmaceutical sciences
|November 15, 2025
PubMed
概括

新的无脂mRNA疫苗采用烯酸涂层,以提高稳定性和有效性. 这些新型微粒子疫苗克服了当前脂质纳米粒子 (LNP) mRNA疫苗的冷藏和制造挑战.

关键词:
微粒子疫苗 微粒子疫苗喷雾干燥的喷雾干燥方法接种疫苗的交付时间.疫苗 疫苗是一种疫苗.它们是mRNARNA.

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Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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