含的脂可以提高生物可用性和减少缺乏的情况
Zahra Rokhsatzadeh1, Maryam Fanaei1, Giti Emtiazi2
1Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
International journal of biological macromolecules
|November 15, 2025
概括
研究人员开发了新的细菌脂-复合体,以改善的吸收. 这些复合物显示出有希望的溶解性和稳定性,这表明增强补充剂的潜力.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 营养科学 营养科学
背景情况:
- 的生物可用性对骨健康和整体健康至关重要.
- 目前的补充剂在吸收和有效性方面面临挑战.
- 细菌脂具有作为新型传递剂的潜力.
研究的目的:
- 开发和表征基于脂的复合物,以提高生物可用性.
- 评估细胞外脂质复合物 (ELC) 在复合中的疗效.
- 在模拟生理条件下评估开发的复合物的稳定性和可溶性.
主要方法:
- 从Bacillus mojavensis HF.中提取和表征脂 (LP和ELC) 的方法
- 使用CaCO3和CaCl2制备基于ELC的复合物.
- 使用能量分散式X射线光谱 (EDX) 和热重力测量分析 (TGA) 的分析.
- 在模拟肠道条件下的溶解度和颗粒大小分析.
主要成果:
- 细胞外脂复合物 (ELC) 显示出更高的负电荷和更高的CaCO3溶解效率.
- 经EDX确认的含量:ELC/CaCO3中25%,ELC/CaCl2复合体中15%.
- TGA表示的CaCO3复合物具有优越的热稳定性 (>300°C).
- 开发的复合物在模拟的肠液中表现出显著的溶解性,即使存在氧酸.
结论:
- 细菌脂复合物可以有效地形成复合物.
- 这些复合物显示出增强的溶解性和稳定性,表明改善生物可用性的潜力.
- 这项研究提出了开发先进补充剂配方的新方法.
更多相关视频
相关概念视频
Bioavailability Enhancement: Drug Permeability Enhancement
179
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
179
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
186
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
186
Receptor-mediated Endocytosis
110.4K
Overview
110.4K
Calmodulin-dependent Signaling
6.0K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
6.0K
Hormones and Bone Tissue
3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
Bioavailability Enhancement: Drug Solubility Enhancement
208
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
208


