治疗良性前列腺增生和急性闭角玻璃眼之间的阿尔法阻塞剂之间的关联
Sung Uk Baek1, Su Hwan Kim2, Ahnul Ha3
1From the Department of Ophthalmology (S.U.B.), Hallym University Sacred Heart Hospital, Anyang, Korea; Department of Ophthalmology and Visual Sciences (S.U.B.), Dalhousie University, Halifax, Nova Scotia, Canada.
American journal of ophthalmology
|November 15, 2025
概括
在良性前列腺增生症 (BPH) 中使用α阻塞剂显著增加了急性闭角玻璃眼 (AACG) 的风险. 随着药物持续时间的延长,风险会升级,突出显示眼科评估的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病.
- 阿尔法阻断剂经常被处方用于BPH症状.
- 急性闭角光眼 (AACG) 是一种严重的眼部疾病,可能导致视力丧失.
研究的目的:
- 调查BPH使用αα-阻断剂与AACG发病率之间的关联.
- 为了确定使用α-阻断剂的持续时间是否会影响AACG风险.
主要方法:
- 使用韩国国家医疗保险数据 (2002-2022) 进行了回顾性全国性基于人口的队列研究.
- 1: 5倾向得分匹配队列创建了30450名参与者 (5,075个AACG病例,25,375个对照).
- 通过诊断和处方记录确定BPH的α-阻断剂使用;按累计药物持续时间 (≤23天,24-202天,≥203天) 分类.
主要成果:
- 使用α-阻断剂与AACG的风险增加显著相关 (调整后HR,1.52;95% CI,1.40-1.66).
- 观察到一种剂量-反应关系:随着更长的α-阻断剂暴露时间,AACG发生率增加.
- 发生率从≤23天的0.15%到≥203天的0.41%不等.
结论:
- 对BPH的α-阻断剂使用与AACG风险的显著,持续时间相关的增加有关.
- 在处方α-阻断剂时,建议对眼科进行评估,特别是对于患有角关闭事件风险的患者.
相关概念视频
Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
Open Angle Glaucoma: Treatment
940
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
940
Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers
1.4K
α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
1.4K
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
1.5K
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
1.5K
Antihypertensive Drugs: Direct Renin Inhibitors
1.3K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.3K


