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手握强度不对称性预测死亡风险:英国生物银行的一项前性队列研究

Yuling Li¹, Decheng Li², Ziyang Ren³

¹School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Journal of the American Medical Directors Association

|November 15, 2025

概括

手握强度 (HGS) 的不对称性,特别是主导不对称性,与脆弱性,并发症和死亡风险增加有关. 对称的HGS与更长的寿命有关,强调HGS不对称性作为一个关键的健康指标.

科学领域:

老年学与公共卫生
衰老的生物标志物
流行病学流行病学

背景情况:

低握力 (HGS) 是已知的衰老和死亡生物标志物.
对于HGS不对称的预后价值尚不清楚.
研究HGS不对称性模式可以揭示对衰老和健康结果的洞察力.

研究的目的:

检查HGS不对称模式与脆弱性之间的关联.
为了确定HGS不对称性和并发症之间的联系.
评估HGS不对称性对死亡风险和预期寿命的影响.

主要方法:

利用了308,810名参与者 (37-73岁) 的英国生物库数据.
定义HGS不对称性为HGS比率>10%的差异.
采用后勤回归,考克斯模型和参数生存模型,对混因素进行调整.

主要成果:

主导的HGS不对称性与较高的虚弱风险 (aOR=1.42) 和并发症 (aOR=1.15) 有显著的相关性.
与对称的HGS相比,主导的HGS不对称性显示出13%更高的死亡风险 (aHR=1.13) .
对称的HGS与长寿有关,而主导的HGS不对称性预测了更短的预期寿命.

结论:

HGS不对称性是不良健康状况和死亡率的重要预测因素.
主导的HGS不对称性在健康评估中需要更加重视.
评估HGS不对称性可以改善对健康轨迹和死亡风险的预测.

关键词:

手握强度不对称的手握强度不对称有不利的健康结果.预期寿命预期寿命

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