脑膜炎,炎症性关节炎和肌肉骨超声波在系统性红斑性狼的负担:一个范围审查
Wen Qi1, Sai Yan Yuen2, Mihaela Luminita Popescu3
1W. Qi, MD, CHU de Québec-Université Laval (Division of Rheumatology), Quebec City, Canada; CHU de Québec - Université Laval Research Center, Quebec City, Canada; Université Laval, Quebec City, Canada; Maisonneuve-Rosemont Hospital (Division of Rheumatology), Montreal, Canada; University of Montreal, Montreal, Canada.
The Journal of rheumatology
|November 15, 2025
概括
炎症性关节炎,紧筋膜炎和肠炎在全身性红斑狼 (SLE) 患者中很常见,通常通过肌肉骨超声波 (MSUS) 检测到. 在SLE中,MSUS对于诊断肌炎和亚临床关节炎非常有价值.
科学领域:
- 类风湿病学 类风湿病学
- 肌肉骨成像系统的成像
- 系统性自身免疫性疾病
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,具有多样化的临床表现.
- 肌肉骨的参与在SLE中很常见,但炎症性关节炎,肌炎和肠炎的具体负担需要进一步澄清.
- 肌肉骨超声波 (MSUS) 为评估关节和肌炎症提供了一个敏感的工具.
研究的目的:
- 进行对当前有关成人SLE患者炎症性关节炎,紧筋膜炎和肠炎的患病率和特征的文献进行范围审查.
- 总结与MSUS检测到的这些条件相关的发现.
- 探索MSUS发现与SLE疾病活动之间的关联.
主要方法:
- 从2015年1月到2025年2月,在主要数据库 (PubMed,Embase,Cochrane图书馆) 进行了系统的文献搜索.
- 研究包括了成人SLE患者报告的突炎,突炎或肠炎.
- 排除标准包括儿科研究,rhupus-only研究,小案例系列,评论和摘要.
主要成果:
- 二十四篇文章符合纳入标准,重点关注炎症性关节炎 (20项研究),紧关节炎 (16项研究) 和肠炎 (7项研究).
- 在SLE患者中发现了炎症性脑膜炎,特别是在远端关节,近端关节和四头肌内关节.
- 在SLE患者中,MSUS在33-55%的患者中发现了关节炎,在9-21%的患者中发现了亚临床关节炎,在8-38%的患者中发现了紧关节炎,这些发现与SLE疾病活性指数相关 (SLEDAI,BILAG).
结论:
- 肠炎可能代表SLE中以前未被认可的肌肉骨领域.
- 在SLE患者中,MSUS是一种有价值的诊断工具,可用于识别SLE患者的紧综合炎和亚临床炎症性关节炎.
- 这些发现凸显了MSUS在全面评估SLE肌肉骨参与方面的实用性.
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