诊断过敏性鼻炎和局部过敏性鼻炎
1Division of Allergy & Immunology, Department of Medicine, Queen's Univeristy, Kingston, Ontario, Canada; Allergy Research Unit, Kingston Health Sciences Centre - Kingston General Hospital Site, Kingston, Ontario, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
局部过敏性鼻炎 (LAR) 呈现过敏症状,但在标准测试中显示负结果. 诊断包括鼻腔过敏原测试和检测局部过敏反应的鼻腔特异性免疫球蛋白-E (sIgE).
科学领域:
- 过敏学 过敏学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 过敏性鼻炎 (AR) 是一种常见的疾病,通过临床病史和过敏测试 (如皮肤刺伤测试或血清特异性IgE (sIgE) 等) 诊断出来.
- 一些患者表现出AR症状尽管负面的常规过敏测试结果,表明一个不同的条件.
- 这一部分患者可能患有局部过敏性鼻炎 (LAR),其特征是鼻粘膜产生IgE.
研究的目的:
- 提供当前过敏性鼻炎 (AR) 诊断方法的概述.
- 探索对局部过敏性鼻炎 (LAR) 识别和诊断的新兴见解.
主要方法:
- 对AR目前的诊断方法的审查.
- 讨论LAR的诊断标准和方法,包括鼻过敏原挑测试和鼻SIGE检测.
主要成果:
- 常规的过敏测试 (皮肤刺伤,血清sIgE) 是AR诊断的标准.
- 局部过敏性鼻炎 (LAR) 是通过局部化的鼻腔IgE产生来识别的.
- 鼻过敏原诱导测试和鼻sIgE检测是LAR诊断的关键.
结论:
- LAR代表了过敏性鼻炎的特定表型,需要不同的诊断策略.
- 准确的LAR诊断对于适当的患者管理和治疗至关重要.
- 对LAR病理生理学和诊断的进一步研究是有必要的.
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