在多发性硬化症中对失声症的系统审查
Desi Gutierrez1, Nicole Rinne1
1UCSF Voice & Swallowing Center, Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco.
Journal of voice : official journal of the Voice Foundation
|November 15, 2025
概括
患有多发性硬化症 (MS) 的人表现出各种声音症状,包括听力障碍和呼吸困难. 需要进一步的研究来标准化评估,并了解MS中声乐表现的变化.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响中枢神经系统.
- 语音功能障碍是MS (PwMS) 患者常见但经常被忽视的症状.
- 了解PwMS中声音投诉的范围对于诊断和管理至关重要.
研究的目的:
- 系统地审查和综合PwMS中关于声控诉和演示的现有文献.
- 确定与MS相关的常见声乐症状和客观措施.
- 突出研究方法和成果中的异质性.
主要方法:
- 在主要的科学数据库 (PubMed,Science Direct,Cochrane,ASHAWire) 进行了全面的文献搜索,截至2025年8月.
- 使用乔安娜·布里格斯研究所的检查清单来评估偏见风险.
- 数据综合涉及选票计数与标志测试和叙述总结非比较结果.
主要成果:
- 58项研究,包括最初确定的1140篇文章,符合纳入标准.
- PwMS在自我感知,听觉感知,声学,空气动力学和喉可视化领域呈现出各种声音症状.
- 在统计学上有意义的发现包括增加的语音障碍,呼吸困难,动,闪,并减少了PwMS的最大发音时间与对照组相比.
结论:
- 患有多发性硬化症的人会经历各种各样的声乐症状.
- 研究方法,结果指标和报告中的显著异质性使得最终结论变得复杂.
- 标准化指标和详细的参与者数据对于未来对MS相关声声功能障碍的研究至关重要.
相关概念视频
01:21Larynx
4.1K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
4.1K
01:20Myasthenia Gravis: Overview and Treatment
2.8K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.8K