断片间体积变化与早期肺癌的立体性废弃性放射治疗患者结果之间的关联
Wilson X Mai1, Melissa A Frick2, Scott Jackson1
1Department of Radiation Oncology, Stanford University, Stanford, CA.
Clinical lung cancer
|November 15, 2025
概括
在非小细胞肺癌 (NSCLC) 的肺部立体性除体放射疗法 (SABR) 中,断片间体积变化很常见. 增加的体积与减少的区域和远程复发相关,这表明炎症反应而不是瘤生长.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 临床瘤学临床瘤学
背景情况:
- 对于早期非小细胞肺癌 (NSCLC) 的肺部立体性除体放射疗法 (SABR) 期间的分数间体积变化尚不清楚.
- 这项研究是迄今为止最大的研究,调查了这些体积变化的临床意义及其对疾病控制的影响.
研究的目的:
- 调查肺部SABR治疗早期NSCLC期间分数间体积变化的临床意义.
- 确定体积变化与临床结果之间的关联,包括局部,区域和远程复发.
主要方法:
- 分析了一组121名在2009年至2019年期间接受SABR治疗的NSCLC患者.
- 计算了瘤总体积 (GTV) 和断片间体积 (来自圆束CT).
- 统计分析,包括单变量/多变量回归和细灰色模型,评估了体积变化和复发之间的关系,死亡作为竞争风险.
主要成果:
- 超过一半的瘤 (61.9%) 显示在治疗期间体积增加>10%,11.1%显示下降.
- 在体积增加和局部复发之间没有发现显著的相关性.
- 增加的分数间体积与区域和远程复发有负面关联.
结论:
- 显著的放射体积变化在NSCLC的肺SABR中很常见.
- 这些体积变化似乎不会对局部瘤控制产生负面影响.
- 增加的放射体积可能与区域和远程复发的减少有关,可能是由于免疫反应,这表明适度的规划目标体积 (PTV) 扩张可能足够.
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