在乳腺磁共振成像检测中,种族差异对基因细胞增强的定量背景有所不同
Mattia A Mahmoud1, Christine E Edmonds2,3, Bruno Barufaldi3
1Department of Biostatistics, Epidemiology, & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cancer
|November 16, 2025
概括
黑人女性在MRI上表现出较高的定量背景对酶体增强 (BPE),独立于其他危险因素. 这一发现表明,BPE可能会改善乳腺癌风险预测,并减少黑人妇女的差异.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 黑人女性的绝对定量乳腺密度较高,但主观BI-RADS密度得分低于白人女性.
- 在MRI上背景体增强 (BPE) 与乳腺癌风险有关,可能有助于风险分层.
研究的目的:
- 为了评估黑人和白人女性之间的定量BPE差异.
- 确定乳腺癌风险因素是否调解了BPE中的这些种族差异.
主要方法:
- 一项横截面研究分析了1202名40-74岁的女性 (200名黑人,1002名白人),她们的乳房图阴性.
- 乳房MRI数据被用于量化BPE,控制BI-RADS密度,纤维腺组织体积和其他共变量.
主要成果:
- 黑人女性的BPE数量明显高于白人女性 (中位数差异1.51),独立于共变量.
- 较少的黑人女性被归类为具有极其密集的乳房,但相似比例显示高质量的BPE.
- 没有确定的风险因素影响了在定量BPE中观察到的种族差异.
结论:
- 黑人女性的BPE数量较高,尽管BI-RADS密度较低,表明BPE捕捉了乳腺组织的独特特征.
- 将BPE纳入乳腺癌风险模型可以提高性能,并减轻不同人群风险预测中的差异.
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