针对抗塞法胺抗性Pseudomonas aeruginosa的毒性基因进行分析:在伊拉克五家医院进行了一项综合性研究
Safae Abdalhamid Bdawi1, Saleem Obaid Gatia Almawa2, Abdurrahman Ayvaz3
1Graduate School of Natural and Applied Science, Erciyes University, Kayseri, Turkey.
Pakistan journal of pharmaceutical sciences
|November 16, 2025
概括
抗生素耐药性Pseudomonas aeruginosa是一种日益增长的威胁. 在伊拉克,35%的伤口感染分离物是抗塞夫塔齐的,发现了常见的耐药基因.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 遗传学 是一个遗传学.
背景情况:
- Pseudomonas aeruginosa 是严重皮肤感染的重要原因.
- 全球抗生素耐药性增加对治疗P. aeruginosa感染构成了重大挑战.
- 在全球范围内,P. aeruginosa的抗塞法胺耐药性越来越令人担忧.
研究的目的:
- 从伊拉克的伤口和烧伤患者中分离和识别P. aeruginosa.
- 为了确定这些隔离物中抗胺耐药性的流行率.
- 在耐药P. aeruginosa菌株中识别关键的抗生素耐药性和毒性基因.
主要方法:
- 在伊拉克五家医院 (从2022年1月至5月) 收集了283名受伤和烧伤患者的样本.
- 对P. aeruginosa的隔离和鉴定.
- 常规和实时PCR用于检测耐药基因 (pelF,blaGES).
- 在特定隔离物中对pelF基因进行生物信息序列分析.
主要成果:
- 从283个样本中确定了117个P. aeruginosa分离物.
- 35.04%的P. aeruginosa分离物表现出对Ceftazidime的耐药性.
- 鉴定出 pelF 和 blaGES 基因是耐药分离物中最常见的耐药基因.
- 序列分析显示,SE36分离物中病毒性基因的高流行率.
结论:
- 伊拉克的P. aeruginosa分离物中很大一部分对ceftazidime.有耐药性.
- 识别pelF和blaGES基因可以了解抵抗机制.
- 了解这些耐药性和毒性模式对于开发针对该地区P. aeruginosa的向治疗策略至关重要.
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