巴基斯坦辛德省的尿路感染的趋势和模式,重点是抗万科素的肠球菌
Rao Muhammad Abid Khan1, Ali Nadeem1, Muhammad Irfan2
1Sindh Institute of Urology and Transplantation (SIUT), Sindh Institute of Medical Sciences (SIMS), Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|November 16, 2025
概括
尿路感染 (UTI) 影响22%的患者,而抗万科米辛抗性肠球菌 (VRE) 越来越令人担忧. 研究确定了耐药性机制,并突出了Morganella morganii作为一种新兴的病原体.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 尿路感染 (UTI) 是一个常见的临床诊断.
- 抗菌素抗性肠道球菌 (VRE) 是全球和巴基斯坦尿路感染的重要原因,而且在不断增加.
- 了解局部尿路感染模式和VRE抵抗机制对于有效治疗至关重要.
研究的目的:
- 确定在巴基斯坦辛德省的尿路感染的流行率和模式.
- 为了研究VRE分离物的潜在抵抗机制.
- 识别新出现的泌尿病原体并评估抗菌素敏感性.
主要方法:
- 使用传统细菌识别方法分析了33,272个尿样.
- 通过Kirby-Bauer和E测试进行抗生素敏感性测试,以检测最小抑制度.
- 使用万科米辛和提科普拉宁盘体检测VRE的表型检测.
主要成果:
- 总体而言,尿路感染的患病率为22%,其中受影响最大的是生育年龄的妇女和老年人.
- 大肠杆菌是主要的格拉姆阴性病原体 (47.6%),而菌是主要的格拉姆阳性病原体 (46%).
- 抗万科素抗性肠球菌 (VRE) 的患病率为16.3%,其中E. faecium (74.8%) 是最常见的. 所有Enterococci都对塞福他西姆,安皮西林和co-amoxiclav有耐药性,但对linezolid敏感. 摩根氏菌 (Morganella morganii) 已成为尿路感染的第四大原因.
结论:
- 在巴基斯坦,Enterococci中的万科米辛耐药性翻了一番,需要紧急关注.
- 在E. faecium中,VanA表型是普遍存在的,而VanB表型存在于20%的E. faecalis中.
- 针对VanRS系统提出了对抗VRE感染的潜在治疗策略.
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