相关实验视频

Updated: Jan 6, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

乳腺癌患者的微RNA表达,综合性审查

Larissa Fernanda Campos Moreira da Silva¹, Fabiana Pirani Carneiro^2,3, Andrea Barretto Motoyama^4,5,6

¹School of Medicine, University of Brasília (UnB), Military Hospital of the Brasília Area, Brasília, Federal District, Brazil.

Journal of surgical oncology

|November 16, 2025

概括

微RNAs (miRNAs) 显示出作为乳腺癌检测,预后和治疗预测的生物标志物的巨大潜力. 这些分子可以通过液体活检获得,为精准医学和改善患者结果提供了一个有希望的途径.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

微RNA (miRNA) 是参与基因调节的小型非编码RNA.
异常miRNA表达与包括乳腺癌在内的各种癌症有关.
目前用于乳腺癌的诊断和预后工具可以通过新的生物标志物来增强.

研究的目的:

对乳腺癌中差异表达miRNAs的当前文献进行审查和综合.
在乳腺癌管理中识别具有诊断,预后和预测价值的miRNA.
探索miRNAs作为乳腺癌精准医学生物标记物的潜力.

主要方法:

2005年至2023年间发表的42篇文章的综合性审查.
对报告乳腺癌患者不同阶段miRNA表达的研究进行分析.
专注于被确定为潜在的诊断,预后或预测标记物的miRNAs.

主要成果:

多个miRNAs对乳腺癌的诊断和预后具有显著的潜力.
特定的miRNAs (例如,miR-21,miR-155,miR-200家族) 始终与临床参数相关.
通过液体活检可以访问miRNAs,从而实现非侵入性监测.

结论:

miRNAs是早期检测,分子亚型和乳腺癌治疗反应预测的有希望的生物标志物.
液体活检可访问的miRNA可以补充传统方法,以提供个性化乳腺癌护理.
对miRNA的进一步研究可以显著改善临床决策和患者的结果.

关键词:

乳腺癌乳腺癌乳腺癌基因表达的基因表达方式综合性审查是一个综合性审查.这是一个微型RNA.分子生物标志物分子生物标志物

更多相关视频

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...