生物年龄加速与社区获得肺炎的住院负担之间的关联:一个队列研究
Biying Wang1,2,3, Chen Qian2,3, Liping Yi2,3
1Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
GeroScience
|November 16, 2025
概括
生物年龄 (BA) 加速增加了社区获得性肺炎 (CAP) 住院和死亡的风险,特别是在老年男性中. 这一发现可能有助于识别早期干预的高风险个体.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 生物统计学 生物统计学
背景情况:
- 社区获得性肺炎 (CAP) 是死亡的一个重要原因,特别是在老年人中.
- 生物衰老 (BA) 加速与与年龄相关的疾病有关,但其对CAP等传染病的影响尚不清楚.
研究的目的:
- 研究生物衰老加速与CAP住院和死亡风险之间的关联.
- 探索生物衰老加速与CAP医院住院时间之间的关系.
主要方法:
- 分析了上海郊区成年人群和生物银行的47,181名参与者的数据.
- 使用克莱梅拉-双倍 (KDMAge),表型年龄 (PhenoAge) 和恒温失调 (HD) 方法估计BA.
- 应用时间依赖的考克斯回归和通用线性模型来评估CAP结果和逗留时间.
主要成果:
- 增加生物年龄加速 (KDMAge,PhenoAge,HD) 与更高的CAP住院和死亡风险显著相关.
- 每增加1 SD的KDMAge加速都与7%更高的CAP住院风险和56%更高的CAP死亡风险相关联.
- PhenoAge加速和日志 (HDAge) 与长时间住院有关,男性和60岁及以上的个人有较高的风险.
结论:
- 加快的生物年龄是CAP住院和死亡的重要风险因素.
- 生物年龄可以作为一种有价值的生物标志物,用于识别 CAP 风险较高的个体.
- 这些发现表明了针对生物衰老加速的个体的早期干预的潜力.
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