相关实验视频

Updated: Jan 11, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

PM_2.5对肠道生理学,微生物群和代谢物的影响

Xuanzhen Yu¹, Zhiying Qiu¹, Xiang Zeng²

¹School of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, Zhejiang 310053, China.

Ecotoxicology and environmental safety

|November 16, 2025

概括

细颗粒物 (PM2.5) 暴露会通过改变微生物群和代谢物,导致炎症和疾病,损害肠道健康. 控制PM2.5污染对于保持肠道完整性和预防慢性疾病至关重要.

科学领域:

环境健康环境健康
微生物学微生物学
毒理学毒理学毒理学

背景情况:

微粒颗粒物 (PM2.5) 是全球主要的健康风险.
新出现的证据将PM2.5暴露与通过肠介导途径的慢性疾病联系起来.
这些途径涉及全身炎症,氧化应激,以及肠道屏障完整性的破坏.

研究的目的:

审查PM2.5暴露对肠道结构,微生物群和代谢物的影响.
阐明PM2.5引起的肠道变化与全身健康之间的机制联系.
突出PM2.5污染控制对肠道健康的重要性.

主要方法:

对调查PM2.5对肠道影响的研究进行文献综述.
对PM2.5引起的肠道屏障功能的改变的研究分析.
检查详细说明肠道微生物群组成和代谢物概况变化的研究.

主要成果:

暴露于PM2.5会通过减少奥克卢丁和ZO-1表达来破坏肠道屏障的完整性.
观察到肠道微生物组合的显著变化,包括增加的乳酸菌,菌,菌和阿克尔曼西亚,以及减少的Bacteroidetes和SCFA产生细菌.
代谢干扰包括SCFA合成受损和酸丁胆代谢失调.

结论:

由PM2.5引起的肠道微生物群和代谢物转移会损害肠-大脑轴的功能.
这些肠介导作用有助于全身炎症和慢性疾病的发展.
有效的PM2.5污染控制对于维护肠道健康和预防疾病至关重要.

关键词:

暴露暴露暴露我们的肠道微生物群.代谢物的代谢物.在PM中{2.5)身体结构的生理结构.

更多相关视频

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...