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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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这种Streptococcus suis ble基因并没有编码功能性白色胺素抗性蛋白质.

Ashley Belinfante1, Janel Kolar1, Sarah M Shore2

  • 1Oak Ridge Institute for Science and Education, United States Department of Energy, Oak Ridge, TN, USA; National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA.

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单独的Streptococcus suis具有一个ble基因,但它不会赋予白菌素耐药性. 这项研究发现,尽管观察到耐药性,但在测试的S. suis菌株中没有发现功能性白素耐药性蛋白.

关键词:
抗微生物耐药性 抗微生物耐药性抗白素的耐药性 抗白素的耐药性这是一种Streptococcus suis.

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科学领域:

  • 微生物学 微生物学
  • 基因组学就是基因组学.
  • 抗微生物耐药性 抗微生物耐药性

背景情况:

  • 瑞士杆菌 (Streptococcus suis) 是一种严重的动物传染病原体,影响着猪和人类的健康,造成经济损失.
  • 获得的白色胺素耐药性是各种环境中已知的问题.
  • 在所有美国S. suis分离物中发现了一种blee基因,预计它会产生bleomycin耐药性,在所有美国S. suis分离物中发现了一种blee基因.

研究的目的:

  • 为了比较预测的S. suis bleomycin耐药性蛋白质的氨基酸序列相似性.
  • 为了功能性地测试S. suis ble基因对白素耐药性的等位基因变异.
  • 为了研究观察到的抗性和非功能性漂白基因之间的差异.

主要方法:

  • 对预测的S. suis bleomycin耐药性蛋白的氨基酸序列的生物信息分析.
  • 功能测试测试S. suis ble基因赋予白素耐药性的能力.
  • 在S. suis菌株的表型检测中检测出白素耐药性.

主要成果:

  • 在预测的S. suis bleomycin耐药性蛋白质中发现了高度的氨基酸序列相似性.
  • 与表征良好的白素抗性蛋白相比,观察到的相似性很弱.
  • 所有测试的S. suis菌株都表现出对白素的表型耐药性.
  • 没有一个被测试的S. suis ble基因编码了功能性白色素抵抗蛋白.

结论:

  • 在S. suis中发现的ble基因不编码功能性白血素抗性蛋白质.
  • 在S. suis观察到的表型白素耐药性背后的机制仍然不清楚.
  • 需要进一步的研究来阐明瑞士链球菌的耐药性机制.