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基托桑基纳米结合激素的输送提高了男性Labeo rohita的生殖效率

Mohd Ashraf Malik¹, Subodh Gupta², Tincy Varghese²

¹ICAR-Central Institute of Fisheries Education, Mumbai, Maharashtra 400061, India; College of Fisheries Science, Birsa Agricultural University, Gumla, Jharkhand 835207, India.

Animal reproduction science

|November 16, 2025

概括

素纳米结合鱼GnRH-a (ChN-sGnRH-a) 与多佩里显著改善了男性Labeo rohita的生殖参数. 即使是半剂量ChN-sGnRH-a与多佩里相匹配商业GnRH-a的疗效,使可持续的水产养殖成为可能.

科学领域:

水产养殖是水产养殖的一种方式.
生殖生物学生殖生物学
纳米技术纳米技术

背景情况:

激素诱导的繁殖对淡水水产养殖至关重要.
传统的性腺激素释放激素类似物 (GnRH-a) 面临着快速降解和高剂量注射造成的压力等挑战.
基托桑纳米载体为增强激素稳定性和递送提供了一个有前途的解决方案.

研究的目的:

评估基托桑纳米结合鱼GnRH-a (ChN-sGnRH-a) 单独和多佩里的生殖疗效,在男性Labeo rohita.
为了比较新型纳米结合物与商业GnRH-a的有效性,并评估剂量降低的好处.

主要方法:

建立了六个治疗组,包括对照组,商业GnRH-a,ChN-sGnRH-a全剂量和半剂量,用多佩里和没有多佩里.
测量了关键的生殖参数,如相对体积,精子运动率和精子数量.
分析了荷尔蒙特征 (,11-基托,17α,20β-二二) 和基因表达 (fshβ, lhβ, fshr, lhr).
用丸组织结构和主要成分分析来评估整体生殖状况.

主要成果:

全剂量ChN-sGnRH-a与多佩里 (T2) 显著优于商业GnRH-a在体积,精子运动性和数量方面.
T2治疗导致血清激素水平达到峰值,并显著提高关键生殖基因的表达.
半剂量ChN-sGnRH-a与多佩里 (T4) 显示出与商业GnRH-a可比的疗效,表明剂量降低的潜力.
主要成分分析证实了基于生殖指数的不同的分组,突出了T2和T4的有效性.

结论:

ChN-sGnRH-a,特别是当与多佩里联合使用时,与Labeo rohita中的商业GnRH-a相比,提供了优越的生殖诱导.
降低ChN-sGnRH-a与多佩里的剂量可以达到与较高剂量的常规治疗方法相匹配的疗效.
这种纳米结合剂方法为水产养殖中的养殖管理提供了一种可持续和低压力方法.

关键词:

繁殖物种繁殖物种繁殖物种基托桑是一种酸盐.药物交付是药物交付的过程.鱼类的繁殖鱼类的繁殖这是一种 GnRH 模拟物.在HPG轴上纳米颗粒纳米颗粒

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