脂肪的差异解释了 normoglycaemia 青少年胰岛素敏感性和分泌特征的种族差异
Yingchai Zhang1, Claudia H T Tam1, Mai Shi1
1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
过度肥胖解释了青少年胰岛素敏感性和分泌的种族差异. 身体质量指数 (BMI) 完全解释了黑人和白人青少年之间的差异,而其他肥胖度量则部分解释了其他种族群体的差异.
科学领域:
- 代谢健康 代谢健康
- 青少年健康 青少年健康
- 健康方面的种族差异.
背景情况:
- 过度肥胖与不同种族群体的胰岛素敏感性和分泌量受损有关.
- 了解代谢特征的种族差异对于有针对性的健康干预至关重要.
研究的目的:
- 调查是否脂肪差异解释了正常糖血症青少年胰岛素敏感性和分泌的种族差异.
- 量化各种脂肪测量对这些种族变异的贡献.
主要方法:
- 来自四个族群的3,349名正常血糖症青少年 (年龄11.3±1.2岁) 的多民族队列.
- 通过口服葡萄糖耐受性测试评估胰岛素敏感性和分泌特征.
- 通过BMI,腰与身高的比率 (WHtR) 和脂肪质量指数 (FMI) 测量肥胖;统计分析对共变量进行控制.
主要成果:
- 肥胖度的测量解释了西班牙裔的胰岛素敏感性/分泌特征的最大变异 (31.97%-43.56%) 和非西班牙裔白人 (18.09%-24.80%) 的最低变异.
- 身体质量指数 (BMI) 的差异完全解释了非西班牙裔黑人和非西班牙裔白人之间的胰岛素敏感性及其与分泌的平衡的种族差异.
- 肥胖部分解释了其他种族差异,FMI,BMI和WHtR对亚洲人,非西班牙裔黑人和西班牙裔人来说最相关.
结论:
- 肥胖差异部分或完全解释了胰岛素敏感性和分泌特征的种族差异.
- 研究结果提供了关于肥胖如何影响新陈代谢概况的见解,并有助于健康的种族差异.
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