葡萄酒 (Vitis vinifera) 种子提取物减少了静脉逆流时间在静脉瘤患者:VICTORY随机对照试验
SungA Bae1, Hakju Kim2, Nak-Hoon Son3
1Department of Cardiology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.
Journal of vascular surgery. Venous and lymphatic disorders
|November 16, 2025
概括
与单独改变生活方式相比,葡萄酒种子提取物 (VVSE) 显著减少了静脉反流时间,并改善了静脉的患者的症状. 这种天然补充剂为治疗静脉缺陷提供了一个有希望的选择.
科学领域:
- 血管医学 血管医学
- 植物疗法 植物疗法
- 临床试验 临床试验
背景情况:
- 多动脉影响了相当一部分成年人群,尤其是老年人群.
- 虽然众所周知,葡萄酒种子提取物 (Vitis vinifera seed extract,VVSE) 有助于缓解静脉缺陷症状,但其对静脉逆流的影响尚未得到充分证实.
- 这项研究研究了VVSE在减少下肢静脉回流的患者静脉回流的疗效.
研究的目的:
- 评估口服VVSE补充剂对下肢静脉回流时间的影响.
- 为了比较VVSE加上生活方式修改与单独生活方式修改在治疗静脉的疗效.
- 评估VVSE对患者报告的症状和临床严重性得分的影响.
主要方法:
- 一个前性的,开放的,随机对照试验,涉及176名已确认静脉反流的成年人.
- 参与者接受了口服VVSE (150毫克每天两次) 加上生活方式的改变或仅仅是生活方式的改变,持续了12周.
- 测量结果包括平均静脉逆流时间,改善逆流的比例,静脉临床严重性得分 (VCSS) 和慢性静脉不充分性生活质量问卷 (CIVIQ-14) 得分.
主要成果:
- VVSE组在表面和深层静脉中平均静脉逆流时间显著减少.
- 在VVSE组中,更高比例的患者获得了改善的静脉反流.
- 在VVSS和CIVIQ-14分数中,VVSE组经历了卓越的改善,这表明症状得到了更好的缓解.
结论:
- 口服VVSE补充剂有效地显著减少静脉逆流时间在患有静脉的患者.
- 比起单独改变生活方式,VVSE可以更有效地改善患者报告的症状和临床严重性得分.
- 在患者亚组中,VVSE的益处是一致的,在深静脉功能不充分症中显著有效.
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