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在实验性犬感染中,野生类型和E3被删除的2型犬腺病毒的比较致病性

Donglingzi Cao¹, Hui Zhang², Pingping Wang¹

¹Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, 530004, PR China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, 530004, PR China; Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, 530004, PR China.

Microbial pathogenesis

|November 16, 2025

概括

狗类腺病毒2型 (CAdV-2) 导致狗的呼吸系统疾病. 一种新的E3基因变异显示出与野生类型菌株相似的毒性,表明功能冗余并影响了犬类健康监测.

科学领域:

兽医病毒学兽医病毒学
狗的传染病狗的传染病

背景情况:

狗腺病毒2型 (CAdV-2) 是狗感染性呼吸道疾病 (CIRD) 的主要原因.
在狗中,CIRD表现为急性喉炎和支气管肺炎.

研究的目的:

从中国广西的临床病例中分离和描述CAdV-2菌株.
调查这些菌株的致病性,包括一种新的E3基因变异.
与野生类型分离物相比,评估E3突变菌株的毒性.

主要方法:

三种CAdV-2菌株的分离和表征.
在实验中感染了一只狗模型.
临床观察,病毒载量定量和组织病理学检查.

主要成果:

分离了三种CAdV-2菌株,其中一种具有新型E3基因变异 (GXNN01) 具有9-核酸删除.
实验感染导致发烧,呼吸道症状和与CAdV-2相一致的病理变化.
这种E3突变的菌株表现出与野生型菌株相当的毒性.

结论:

在CAdV-2中的E3基因组区域可能具有功能冗余.
这些发现有助于更好地了解CAdV-2的发病过程,并为疫苗开发提供信息.
持续监测对于追踪CAdV-2传播和对狗健康的影响至关重要.

关键词:

狗类腺病毒2型狗的传染性呼吸道疾病 (CIRD)删除E3基因删除分子表征的分子表征.病毒病原发生的病毒病原体.

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