评估图像引导乳腺活检中全静电负荷和恶性病变之间的关联
Lily Kwak1, Saloni Patel1, Gayane Yenokyan2
1Department of Radiology, John Hopkins University, Baltimore, Maryland.
Journal of the American College of Radiology : JACR
|November 16, 2025
概括
较高的静态负荷 (AL),一种衡量压力的措施,与接受图像引导活检的女性恶性乳腺病理的几率增加有关. 这一发现可能会为个性化癌症查策略提供信息.
科学领域:
- 在瘤学瘤学.
- 生理学 生理学 生理学
- 生物统计学 生物统计学
背景情况:
- 静态负荷 (AL) 量化了慢性压力的生理失调.
- 了解AL在乳腺癌病理学中的作用对于风险评估至关重要.
研究的目的:
- 研究在接受图像指导乳房活检的妇女中全静态负荷 (AL) 和恶性病理之间的关联.
主要方法:
- 对253名接受图像指导乳腺活检的女性 (≥18岁) 进行了回顾性队列研究.
- 从心血管,免疫,代谢和脏生物标志物计算的AL.
- 多变量逻辑回归分析了AL和恶性/高风险病理之间的关联.
主要成果:
- 在调整了人口统计和面积剥夺后,较高的AL与恶性乳腺病变的概率增加了22% (OR1.22,95%CI1.03-1.44).
- 当调整为盖尔5年风险评分时,这种关联失去了意义.
- 在AL和高风险乳腺病理之间没有发现显著的关联.
结论:
- 增加的全静电负荷可能与图像导向乳腺活检中的恶性发现有关.
- 这些发现表明AL在个性化乳腺癌查中的潜力.
- 需要进一步的研究来澄清AL在癌症差异中的作用和影响.
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