针对多病症老年人的卫生干预措施的结果措施:系统性审查
Massimiliano Fedecostante1, Paolo Balietti1, Alessia Beccacece1
1Geriatria, Accettazione Geriatrica e Centro di Ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy.
Ageing research reviews
|November 16, 2025
概括
对患有多种慢性疾病的老年人进行的临床试验需要更广泛的结果测量. 专注于独立,身体功能和生活质量对于这个人群至关重要.
科学领域:
- 老年学是一门学科.
- 临床试验 临床试验
- 健康 结果 研究 研究 结果
背景情况:
- 患有多种疾病的老年人经常被排除在临床试验之外.
- 传统的以疾病为中心的终点对这个人群来说是不够的,无法解决脆弱性,功能衰退和残疾.
研究的目的:
- 系统地审查与多病症老年人干预相关的结果.
- 纳入患者和医疗保健专业人员对结果的重要性的观点.
主要方法:
- 按照PRISMA 2020指南进行系统审查,在PROSPERO.中注册.
- 搜索了五个数据库,对60岁以上的患有≥2种慢性疾病的患者进行了定量和定性研究.
- 将结果分为六个领域:身体,精神,心理/社会/一般健康,医疗保健利用/成本,患者行为和护理过程.
主要成果:
- 包括71项研究 (53项定量研究,16项定性研究,2项混合研究).
- 最常见的结果:心理社会/一般健康 (69.0%),护理过程 (52.1%),医疗利用/费用 (49.3%).
- 定性研究强调心理健康结果 (43.8%);患者的主要优先事项是独立性,身体功能和生活质量.
结论:
- 对多种疾病的老年人进行干预研究应该优先考虑独立性,身体功能和生活质量等结果,而不是疾病特异性措施.
- 选择结果必须考虑患者的异质性,脆弱性和预期寿命的相关性和影响.
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