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相关概念视频

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
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肝脏增大:理由,现状和未来方向

Jirapa Chansangrat1, Sameer Gadani2

  • 1Section of Interventional Radiology, Imaging institute, Cleveland Clinic, Cleveland, OH; School of Radiology, Medical Institute, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

Techniques in vascular and interventional radiology
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概括

像PVE和ALPPS这样的肝脏增大技术增强了未来的肝脏残留物 (FLR),使肝癌患者的手术成为可能. 这些方法改善了结果,减少了并发症,改变了肝癌管理.

关键词:
人工智能的人工智能是人工智能.胆瘤是一种胆瘤.肝细胞癌是肝细胞癌.肝脏增大疗法 肝脏增大疗法肝功能测试试验 肝功能测试试验肝脏再生 肝脏再生门静脉栓塞 (portal vein embolization) 是一种可以使门静脉栓塞的方法.

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科学领域:

  • 肝胆道手术 肝胆道手术
  • 手术瘤学手术瘤学
  • 再生医学是一种再生医学.

背景情况:

  • 肝脏增大技术对于管理原发性肝癌和转移至关重要,特别是当未来的肝脏残留物 (FLR) 不足时.
  • 这些技术旨在预防肝切除术后肝衰竭 (PHLF),这是肝切除术后死亡的重要原因.
  • 现有的方法包括门静脉栓塞 (PVE),肝静脉剥夺 (LVD),以及分阶段肝切除术 (ALPPS) 的肝脏分割和门静脉结合.

研究的目的:

  • 审查肝脏癌症管理肝脏增强技术的进展.
  • 探索增加未来肝脏残留物 (FLR) 体积和功能的方法.
  • 讨论功能评估工具的作用和患者选择和结果预测中的新兴创新.

主要方法:

  • 审查已建立的肝脏增大技术 (PVE,LVD,ALPPS).
  • 讨论功能评估工具 (肝胆镜,MRI与肝细胞特异性对比).
  • 探索影响肝脏再生的因素和瘤特异性考虑.
  • 在体积评估中包括人工智能等新兴创新.

主要成果:

  • 肝脏增大技术通过诱导FLR缩,使以前无法手术的患者能够进行治疗性手术.
  • 功能评估工具有助于预测术后结果和评估肝功能.
  • 针对肝细胞癌和胆道恶性瘤等特定疾病需要量身定制的方法.
  • 人工智能显示出增强体积评估和患者选择的潜力.

结论:

  • 肝脏增强方面的进步扩大了肝癌患者的外科治疗资格.
  • 这些技术可以改善瘤的结果,并减少术后并发症.
  • 肝脏增大代表了管理肝癌的变革性方法,为患者提供更好的治疗结果.