适应性应对压力与高风险认知无损老年人的认知性有关
Eleni Palpatzis1,2,3, Joseph J Locascio4,5, Phebe Palmer5
1Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 17, 2025
概括
适应性应对策略增强认知性,独立于阿尔茨海默病 (AD) 病理. 这些策略可能缓冲对认知衰退的负面影响,为认知维护提供潜在的目标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 心理学 心理学 心理学
背景情况:
- 应对策略是影响认知性的可修改因素.
- 阿尔茨海默病 (AD) 病理与认知能力下降有关.
- 应对,AD病理和认知之间的相互作用需要进一步研究.
研究的目的:
- 为了检查适应性应对是否修改了AD病理和认知衰退之间的关联.
- 研究应对策略在认知性中的作用.
- 确定旨在维持认知功能的干预措施的潜在目标.
主要方法:
- 包括来自两个观察队伍的99名认知正常的老年人.
- 评估了应对策略,纵向认知功能 (扩展PACC) 和神经成像 (Aβ和tau PET).
- 采用线性混合效应模型来分析平均5.3年的数据.
主要成果:
- 适应性应对与更好的认知轨迹有关,无论AD病理.
- 较高的水平与较少的适应性应对相结合,预测了加速的认知衰退.
- 图高但更适应性应对的个体保持了认知功能,突出了缓冲效应.
结论:
- 适应性应对策略可能会促进对认知衰退的弹性.
- 专注于增强应对技能的干预措施显示,在患有阿兹海默症风险的人群中,保持认知能力是有前途的.
- 应对策略代表了减轻认知衰退的潜在可修改的目标.
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