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WS9326B的总合成通过一个生物启发的巨乳化战略

Seung Hyun Choi¹, Seok Beom Lee¹, Junhwa Hong¹

¹Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

Organic letters

|November 17, 2025

概括

具有抗血管原性质的环甲类,WS9326B的总合成是使用生物启发的巨乳化策略实现的. 这种高效的方法为生产WS9326B提供了一条新的途径,并推进复杂的环二合成.

科学领域:

有机化学有机化学
药用化学医学化学
自然产品的合成自然产品的合成

背景情况:

WS9326B是一种来自Streptomyces sp.的循环甲酸天然产物. 在SNM55.5中,SNM55.5中,SNM55.5中,SNM55.5中,SNM55中,SNM55中,SNM55中,SNM55中,SNM55中,SNM55中,SNM55中,SNM55中,SNM55中.
它具有独特的 (Z) - 丁烯酸酸侧链,并表现出显著的抗血管性活性.
WS9326B的复杂结构和生物活性使其成为化学合成的目标.

研究的目的:

为了实现WS9326B.的总合成.
开发一个生物启发的巨乳化策略,用于复杂的环二合成.
为生产WS9326B提供一个多功能平台,以便进一步研究.

主要方法:

合成采用了顺序的胺合.
石化化被用于宏循环化.
整体合成在13个最长的线性步骤中完成.

主要成果:

成功完成了WS9326B的总合成.
展示了一种生物启发的巨乳养殖策略.
合成是高效的,只需要13个最长的线性步骤.

结论:

开发的合成路线为WS9326B生产提供了一个多功能平台.
这项工作为复杂的环二的宏循环化策略提供了新的视角.
这种合成有助于对WS9326B.进行未来的生物和药物研究.

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