皮秒激光治疗梅拉斯玛后的低颜色:一个案例系列
Xiaozhun Hang1, Davin Sui Lim2
1Mowbray Park Medical and Dermatology, Brisbane, Queensland, Australia.
Lasers in surgery and medicine
|November 17, 2025
概括
皮秒激光 (PSL) 对黑色素瘤的治疗很少导致低颜色,即使在较低的设置. 这种罕见的副作用可能是由于热积累,可能不会重新染色,需要仔细监测.
科学领域:
- 皮肤病学 皮肤病学
- 审美医学是一种美学医学.
- 激光疗法是一种激光疗法.
背景情况:
- 皮秒激光器 (PSL) 越来越多地用于治疗黑色素瘤,因为与Q开关激光器 (QSL) 相比,它具有有利的安全性.
- 低颜色是激光治疗的潜在副作用,但其发生率和特征在PSL治疗黑色素瘤后并未得到充分证实.
研究的目的:
- 为了调查发生和结果的皮秒激光治疗后的低颜色在患有黑色素的患者.
- 探索在PSL治疗后导致低颜色形成的潜在因素.
主要方法:
- 在2021年至2025年期间,对患者进行了回顾性图表审查,这些患者因梅拉斯马而接受了PSL治疗.
- 分析治疗参数,包括波长 (755和/或1064-nm),低流量和会话间隔 (4-12周).
- 对受影响的皮肤进行组织学检查和对再染色的后续评估.
主要成果:
- 在796名接受治疗的患者中,发现了4例 (0.38%) 的低颜色化病例.
- 低颜色发生在波长和光束形状上,其特点是减少黑色素颜料和黑色素体含量,但保持了黑色素细胞密度.
- 在6个月的随访期内没有观察到显著的再颜色化;没有发现后炎性多颜色化 (PIH) 的病例.
结论:
- 低颜色是一种罕见但可能的PSL治疗黑色素瘤的不良影响,即使在保守的设置.
- 由于手动缓慢而导致热束堆叠可能会导致局部热积累和随后的低颜色化.
- 临床人员的警对于监测低颜色化至关重要,因为重新颜色化可能具有挑战性;需要进一步的研究来确定风险因素并优化治疗方案.
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