功能连接器介绍了成年人一生中健身和认知之间的关联
Junaid S Merchant1, Jeremy J Purcell2, Daniel D Callow3
1Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, Maryland, USA.
Human brain mapping
|November 17, 2025
概括
心血管健康 (CRF) 对于大脑健康至关重要. 较高的CRF与更好的记忆和执行功能有关,通过腹部注意力和边缘网络中的特定大脑连接模式.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 衰老研究研究 衰老研究
背景情况:
- 心血管健康 (CRF) 越来越多地被认为对神经和认知功能有好处,特别是在老年人中.
- 了解将CRF与认知联系起来的神经机制对于开发在衰老过程中维持大脑健康的干预措施至关重要.
研究的目的:
- 研究中年和老年人中CRF,认知功能 (情节性记忆和执行功能) 和功能连接 (FC) 配置文件之间的关系.
- 测试与CRF相关的FC配置文件是否介导或缓解CRF与认知表现之间的关联.
主要方法:
- 使用了人类结合体项目 (HCP) 衰老数据集 (N=378,年龄36-100岁).
- 采用基于连接组的预测建模 (CPM) 来识别可预测CRF,情节性记忆和执行功能的FC.
- 检查了已识别的FCs对CRF-认知关系的调解和适度效应,对年龄,教育和性别进行控制.
主要成果:
- 在与CRF相关的FC配置文件和与腹部注意力和边缘网络中的认知功能相关的FC配置文件之间发现了显著的重叠.
- FC概况完全介绍了CRF和情节性记忆之间的关系.
- FC 配置文件部分调解了CRF与执行功能之间的关系,没有观察到缓和效应.
结论:
- 腹部注意网络 (VAN) 内的功能连接,特别是涉及右中半岛和右下额头,以及边缘网络,作为一种神经机制,将CRF与成年期的认知功能联系起来.
- CRF代表了一个可修改的目标,特定的FC配置文件可以作为脑健康干预措施的生物标志物,旨在增强老化中的神经认知健康.
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