使用有机晶体管用于诊断应用的电可读侧向流量测试
María Jesús Ortiz-Aguayo1, Carme Martínez-Domingo1,2, Diego Gutiérrez1
1Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.
Advanced materials (Deerfield Beach, Fla.)
|November 17, 2025
概括
本研究介绍了一种新型的,可重复使用的生物传感器,将电解质接有机场效应晶体管 (EGOFET) 与纸质流体相结合,用于快速,便携式诊断. 该设备在护理点检测人体免疫球蛋白G时具有高灵敏度和选择性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 电解质开关有机场效应晶体管 (EGOFET) 提供超敏感的,无标签的生物感知能力.
- 目前的局限性包括微流体挑战和复杂的测试,阻碍了便携式诊断应用.
- 基于纸质的侧流 (LF) 免疫试验对于临床诊断很重要,但其检测灵敏度较低.
研究的目的:
- 通过将EGOFET与LF纸张流体进行集成,开发一种简单,可重复使用和便携式生物传感器.
- 创建一个具有成本效益的PoC诊断测试,以快速检测人类免疫球蛋白G (IgG) 的结果.
- 克服现有的生物传感技术在综合诊断方面的局限性.
主要方法:
- 一个EGOFET传感器的制造与基于纸张的侧流流体集成.
- 生物传感器用于人类免疫球蛋白G检测的验证.
- 开发了一种便携式原型,使用小型电子阅读器连接到智能设备.
主要成果:
- 在大约20-30分钟内取得了快速检测结果.
- 展示了广泛的线性范围,高选择性和人类免疫球蛋白G检测的优良可重现性.
- 报告了人类免疫球蛋白G的0.1女性分子 (fm) 的低检测极限.
结论:
- 集成的EGOFET-LF系统为PoC诊断提供了一种可重复使用,便携且具有成本效益的解决方案.
- 这项技术满足了对低成本PoC测试的需求,并推进了数字横流测定.
- 开发的系统为下一代综合诊断平台提供了一个有希望的基础.
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