术前系统性炎症反应指数与术后复发在肝内胆道结石患者中的相关性
Musu Pan1, Xiaolin Ye2, Lei Zhou3
1Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, 063000 Tangshan, Hebei, China.
Annali italiani di chirurgia
|November 17, 2025
概括
手术前的全身免疫炎症反应指数 (SIRI) 可以预测肝脏内胆道结石 (IHBDS) 的复发. 高SIRI,之前的手术和胆红素水平是IBHDS复发的关键风险因素.
科学领域:
- 肝胆道手术 肝胆道手术
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 肝脏内胆道结石 (IHBDS) 由于胆汁停滞,感染和炎症,其复发率很高.
- 在IHBDS的发展,进展和复发中,炎症反应至关重要.
研究的目的:
- 评估手术前系统性免疫炎症反应指数 (SIRI) 对IHBDS患者术后复发的预测性表现.
主要方法:
- 对152名接受手术切除的IBHDS患者的回顾性分析.
- ROC曲线分析以确定SIRI和其他炎症标志物 (SII,NLR,MLR,PLR) 的最佳切断值.
- 多变量后勤回归用于识别复发的独立风险因素.
主要成果:
- 与其他炎症指数相比,SIRI显示出更好的预测性能 (AUC = 0.756).
- 复发的独立风险因素包括之前的IBHDS手术,手术前SIRI升高 (OR=1.81),以及高总 bilirubin (OR=1.07).
结论:
- 术前SIRI是一种新的,独立的生物标志物,用于预测IBDS复发.
- 将SIRI与之前的胆管手术史和胆红素水平相结合,有助于风险分层和手术规划.
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