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Updated: Jan 6, 2026

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
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Published on: April 17, 2017

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/交换用于评估含甲的酸性化合物中性稳定性

Zaikuan Josh Yu1, Cristobal Morfin1, Thomas Paul2

  • 1Department of Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California 94404, United States.

Analytical chemistry
|November 17, 2025
PubMed
概括

酸性化合物,如谷氨胺和 thiazolidinediones 可以 racemize,影响药物特性. 化增强了性稳定性,而PROTACs表现出比分子粘剂更大的稳定性.

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