来自脱细胞化组织的基于细胞外矩阵的材料:再生医学的机遇,挑战和未来方向
Madeline Laude1, Vasiliki Kolliopoulos2, Antonios G Mikos2
1Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA.
Advanced healthcare materials
|November 17, 2025
概括
脱细胞化细胞外基质 (dECM) 生物材料在组织再生方面表现有前途. 制造技术的进步提高了dECM的应用,但标准化和生物活性保留仍然是临床翻译的关键挑战.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 细胞外基质 (ECM) 生物材料作为组织再生的诱导支架.
- 脱细胞化ECM (dECM) 生物材料保留了原生ECM生物活性,指导细胞过程.
- 在软组织修复,心脏重建和泌尿器科干预方面,dECM的临床成功被注意到.
研究的目的:
- 审查当前dECM生物材料的临床使用情况.
- 讨论dECM生物材料制造方面的进展.
- 为了识别dECM产品临床转化中的障碍.
主要方法:
- 审查目前的dECM片和粉末的临床应用.
- 分析最近的制造进步,包括电和3D打印.
- 讨论脱细胞化标准化,生物活性优化和机械兼容性方面的挑战.
主要成果:
- 目前dECM的临床使用主要局限于原生板或粉末.
- 先进的制造方法,如电和3D打印,扩大了dECM的应用.
- 在标准化脱细胞化,保持生物活性和确保机械兼容性方面仍然存在重大挑战.
结论:
- dECM生物材料为组织再生提供了显著的潜力.
- 制造方面的进步正在扩大dECM的临床实用性.
- 过程的标准化和克服翻译障碍对于未来的dECM开发至关重要.
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