在MR条件下血液的液压体内表征.
Dominik T Schulte1, Marcel Renggli2, Henning Richter3
1Institute for Dynamic Systems and Control, ETH Zurich, Zurich, Switzerland.
Artificial organs
|November 17, 2025
概括
为新生儿心脏手术开发了三种新的MR条件血. 这些与MRI兼容,并满足心肺旁路系统的液压要求,使未来的脑损伤研究成为可能.
科学领域:
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
- 心血管外科心血管外科
背景情况:
- 新生儿心脏外科手术经常使用心肺绕道 (CPB),由于血液体积小,需要在患者附近使用心肺机器 (HLM).
- 在对接受CPB的新生儿进行外科手术期间脑损伤的研究中,一个重大挑战是缺乏用于心肺机器 (HLM) 的MR兼容血.
- 这项研究启动了MR条件的HLM的开发,重点是MR兼容的血硬件和性能验证.
研究的目的:
- 开发和评估用于新生儿心脏外科手术的新型血原型的MR兼容性和液压性能.
- 评估创建MR条件心肺机器 (HLM) 的可行性,用于先进的外科手术前脑损伤研究.
主要方法:
- 设计了三种不同的MR条件血原型:一个滚筒,一个非封闭式滚筒和一个离心.
- 通过评估MRI扫描期间潜在的成像干扰,严格测试了MRI兼容性.
- 使用在模拟循环试验台上生成的压力流动图来量化液压性能.
主要成果:
- 这三种原型均未对MRI成像产生干扰,尽管信号噪声比 (SNR) 略有降低,但仍然保持了足够的图像质量.
- 滚筒和非遮蔽式滚筒在不同压力下表现出稳定的流量特性.
- 离心显示了压力依赖的性能,所有都产生了非脉冲性流量.
结论:
- 开发的血原型符合基本的MR条件和液压性能标准.
- 这些MRI条件在新生儿心脏外科手术期间有望被纳入MRI导向研究.
- 这项工作是实现新生儿CPB手术期间实时MRI监测的关键第一步.
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