Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.3K
Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

52.2K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
52.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effects of <i>IGF2 P2</i> promoter methylation levels in umbilical cord blood on the relationship between PM<sub>2.5</sub> chemical components and birth weight.

International journal of environmental health research·2026
Same author

Correction to "Magnolol Hybrid Nanofibrous Mat with Antibacterial, Anti-Inflammatory, and Microvascularized Properties for Wound Treatment".

Biomacromolecules·2026
Same author

Kingdom-wide evolutionary characterization of RNA editing factors in Archaeplastida.

Molecular biology and evolution·2026
Same author

IGFBP3 As a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma: A Multi-Cohort Analysis.

Journal of clinical laboratory analysis·2026
Same author

Glyphosate Induces Liver Macrophage Pyroptosis via Mitochondrial Damage-Mediated cGAS-STING Activation.

Toxics·2026
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026

相关实验视频

Updated: Jan 11, 2026

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.2K

2026年EWAS开放平台:一个深度整合的资源,用于全表观基因组协会研究.

Fei Yang1,2, Zhuang Xiong3, Wenting Zong1,2

  • 1National Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.

Nucleic acids research
|November 17, 2025
PubMed
概括

现在,EWAS开放平台提供了扩展的全表观基因组关联研究数据和工具. 这次升级增强了数据集成,并包括用于探索复杂特征表观遗传学的AI驱动服务.

更多相关视频

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.6K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

相关实验视频

Last Updated: Jan 11, 2026

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.2K
Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.6K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

科学领域:

  • 基因组学就是基因组学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 全表观基因组关联研究 (EWAS) 对于理解复杂特征的表观基因基础至关重要.
  • 此前,EWAS开放平台提供了策划协会,甲基化数据和分析工具.

研究的目的:

  • 为EWAS开放平台进行重大升级,增强其数据资源,分析能力和用户服务.
  • 为研究复杂特征的研究人员提高EWAS数据的可访问性和实用性.

主要方法:

  • 扩展了EWAS地图集,拥有超过80万个关联和17000个因果关系.
  • 丰富了EWAS数据中心的超过18万批次纠正样本,包括新的Illumina MethylationEPIC v2.0数据.
  • 在数据,知识和工具包组件之间引入增强的互操作性.
  • 整合人工智能辅助的问答服务,用于交互式数据探索.

主要成果:

  • 现在,EWAS地图包含了更精确的关联和因果关系.
  • 该EWAS数据中心拥有一个更大的,批量纠正的数据集,包含了先进的甲基化分析.
  • 互操作性增强允许统一的数据检索,总结和可视化.
  • 人工智能服务可以进行交互式查询,并从EWAS数据中生成定制的见解.

结论:

  • 升级后的EWAS开放平台提供了大大改进的数据资源,分析工具和服务功能.
  • 这种增强提供了更先进的支持,通过表观基因组镜头剖析复杂的分子机制.
  • 该平台通过集成数据和人工智能驱动的洞察力,通过综合数据和人工智能驱动的洞察力,更深入地探索复杂特征中的表观遗传学.