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Updated: Jan 11, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

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GSK3β指导染色体修复途径的选择,以支持BRCA1-独立的PARP抑制剂敏感性

Justin W Leung1, David Gius1,2

  • 1Department of Radiation Oncology, Mays Cancer Center at University of Texas Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, San Antonio, Texas, USA.

The Journal of clinical investigation
|November 17, 2025
PubMed
概括

糖原合成酶激酶-3β (GSK3β) 通过酸化53BP1.1来调节DNA修复路径的选择. 这种酸化将DNA双链断裂修复转向同源重组,影响癌症治疗.

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