对系统性炎症生物标志物的多中心研究,用于iCCA患者的预后评估
Yun Tao1, Benjie Xu2, Jie Tang1
1Department of Intervention, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China.
全免疫炎症值 (PIV) 是肝内胆管癌 (iCCA) 的优异预后生物标志物,与传统的炎症标志物相比. 这种随时可用的指标有助于预测患者的生存结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 在肝内胆管癌 (iCCA) 中,系统性炎症生物标志物的预后值是不确定的.
- 需要确定iCCA患者结果最有效的预测指标.
研究的目的:
- 在iCCA中比较12种系统性炎症生物标志物的预测性能.
- 确定最有效的生物标志物来预测iCCA患者的整体存活率 (OS) 和无病存活率 (DFS).
主要方法:
- 对接受治疗切除的312名iCCA患者的回顾性分析.
- 对12种系统性炎症生物标志物的评估,用于OS和DFS的预测.
- 使用C指数,时间AUC和Brier分数评估预后准确性;开发名ograms.
主要成果:
- 全免疫炎症值 (PIV) 在所有生物标志物中显示出最强的预后性能.
- 高PIV独立预测了不良的OS和DFS (P<0.001).
- 将PIV与临床病理因素结合在一起的诺米克图改善了生存预测的准确性.
结论:
- 与传统指数相比,PIV为iCCA提供了更优质,更具成本效益的预测价值.
- PIV是iCCA预后的一个易于获得的生物标志物.
- 在外部队列中对PIV的前性验证是合理的.
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