经过两次非侵入性染色体查的冷解芽细胞的临床结果

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Yu Qiao^1,2, Shuangshuang Geng^1,2, Bin Zhang^1,2

¹Reproductive Medicine Department, Hebei Maternity Hospital, Shijiazhuang, China.

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|November 17, 2025

概括

非侵入性染色体查 (NICS) 的双解程序不会对胚胎质量或临床结果产生负面影响. 使用解培养基重新分析胚胎,可以将活产率与单次冷-解周期相比较.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
遗传学是一个遗传学.

背景情况:

人类胚胎的冷保存和解对于辅助生殖技术至关重要.
非侵入性染色体查 (NICS) 为植入前遗传检测提供了一种不那么侵入性的方法.
重复的冷解周期对胚胎质量和NICS疗效的影响需要研究.

研究的目的:

评估双重冷解程序对胚胎质量的影响.
评估NICS在双重冷解周期和单一冷解周期后的临床结果.
为了确定使用解培养基进行NICS再分析的成功率.

主要方法:

一项回顾性研究包括275名患者和1443个接受NICS的胚胎.
根据NICS的成功,患者被分为单次冷解和双次冷解组.
分析了临床结果,包括检测成功率和活产率.

主要成果:

尼克斯检测失败率为6.7%.
胚胎形态分级在第二次冷解周期后显示出最小的变化.
两组之间在临床怀孕,流产,持续怀孕或活产率方面没有发现显著差异.

结论:

双解程序不会对胚胎质量或临床结果产生不利影响.
当初试验失败时,使用解培养基重新应用NICS是一个可行的选择.
在NICS中,通过双重冷解周期,可以实现相似的繁殖成功.

关键词:

在 NICS 检测故障时,会出现故障.胚胎囊细胞转移是什么意思临床怀孕的结果.经过冷解的胚胎非侵入性染色体查是一种非侵入性染色体查.

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