在捐赠体试管婴儿周期中影响卵细胞产量和胚胎质量的因素:回顾性队列研究
Pin-Yao Lin1,2, Chun-I Lee1,2,3,4, Hsiu-Hui Chen1,2
1Division of Infertility, Lee Women's Hospital, Taichung, Taiwan.
Frontiers in endocrinology
|November 17, 2025
概括
反米勒尔激素 (AMH) 预测了捐赠者IVF中的卵细胞产量,而BMI和刺激协议影响了胚胎质量. 个性化策略优化结果,尽管协议差异.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 卵巢刺激 卵巢刺激
背景情况:
- 优化卵细胞产量和胚胎质量对于成功的捐赠者IVF至关重要.
- 抗穆勒尔激素 (AMH) 是已知的卵细胞数量的预测因子.
- 捐赠者的特征和刺激方案可以影响胚胎发育能力.
研究的目的:
- 确定影响卵子产量和胚胎质量的临床和与协议相关的因素,在大量卵子捐赠者队列中.
- 评估不同卵巢刺激方案和触发方法对试管婴儿结果的影响.
主要方法:
- 追溯分析了584个捐赠者试管婴儿周期.
- 收集了关于捐赠者人口统计 (年龄,AMH,BMI,基线荷尔蒙) 和刺激参数 (GnRH对抗剂与PPOS,LH补充,触发方法) 的数据.
- 使用多变量线性回归和倾向得分匹配 (PSM) 来比较结果.
主要成果:
- AMH独立预测卵细胞数量;较高的BMI与较低的受精率相关.
- 与GnRH对抗剂协议相比,孕激素主导的卵巢刺激 (PPOS) 导致较低的第3天优质胚胎和最高质量的母细胞囊率.
- 补充LH显示受精率略有增加;双触发与减少胚胎细胞形成有关,但质量较高的胚胎细胞比例较高.
结论:
- 在捐赠者IVF中,AMH是卵细胞产量的主要预测因子.
- 体重指数,刺激方案和触发方法显著影响胚胎质量.
- 尽管胚胎形态的协议特定变异,但观察到高怀孕和活产率,支持个性化刺激策略.
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